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Highlight on Health - Why you might like to know if your dog is MDR1 positive …..by Tracy Flower

Bikini tested Clear and I'm very relieved about it. I plan on doing the other girls too now.

I used the service provided by Animal Health Trust (AHT). It cost me £60 and I did the ordering of the test kit online and then posted it back to them.  I received the results 6 days later by email.  There are other labs that also provide this service or you can go to your vets for a blood test if you prefer.

Recently the Kennel Club started a database of results of dogs tested for this gene defect. This will help breeders choose a suitable sire/dam for mating so that fewer pups that are affected or carriers are born in the future.

There is lots more information available on the Internet on this subject, I've just given a brief out-line  here.


Tracy Flower



Note from editor: You can read more about the implications for this genetic disorder in our technical website article MDR1 in the Articles section

MDR-1 Gene (Multi Drug Resistant-1 Gene)

Some of you may already know that there is a gene disorder that affects many herding breeds such as Border Collies and Shelties which means they shouldn't have worming tablets containing Ivermectin.

If you have a herding breed dog you may think that you will just avoid those wormers and perhaps use something different. However, what you may not realise, is that there are many other drugs (including anaesthetic drugs) that are also a problem in dogs affected by or carriers of the mutant gene.  

It is possible, through an easy cheek swab DNA test, to find out if your dog is Clear, a Carrier or Affected by the gene mutation.  I recently did this for my youngest collie, Bikini after one of her litter mates died at 2 years old after a routine spay. My vet suggested I have her tested in case this was a factor in what happened.

It is possible, through an easy cheek swab DNA test, to find out if your dog is Clear, a Carrier or Affected by the gene mutation.  I recently did this for my youngest collie, Bikini after one of her litter mates died at 2 years old after a routine spay. My vet suggested I have her tested in case this was a factor in what happened.